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Article

Prophage-dependent recombination drives genome structural variation and phenotypic heterogeneity in <i>Escherichia coli</i> O157:H7

2020-12-02

Abstract excerpt

The human zoonotic pathogen Escherichia coli O157 is defined by its extensive prophage repertoire including those that encode Shiga toxin, the factor responsible for inducing life-threatening pathology in humans. As well as introducing genes that can contribute to the virulence of a strain, prophage can enable the generation of large-chromosomal rearrangements (LCRs) by homologous recombination. This work examine...

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Literature Corpus work
32b4842f-edb8-544a-b7a2-ecd1c4f5bf5e
DOI
10.1101/2020.12.02.407981
Open publication

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