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Extensive genomic diversity and selective conservation of virulence-determinants in enterohemorrhagic Escherichia coli strains of O157 and non-O157 serotypes.

Genome biology - 1 Jan 2007

Ogura Yoshitoshi, Ooka Tadasuke, Asadulghani, Terajima Jun, Nougayrède Jean-Philippe, Kurokawa Ken, Tashiro Kousuke, Tobe Toru, Nakayama Keisuke, Kuhara Satoru, Oswald Eric, Watanabe Haruo, Hayashi Tetsuya

Abstract excerpt

BACKGROUND: Enterohemorrhagic Escherichia coli (EHEC) O157 causes severe food-borne illness in humans. The chromosome of O157 consists of 4.1 Mb backbone sequences shared by benign E. coli K-12, and 1.4 Mb O157-specific sequences encoding many virulence determinants, such as Shiga toxin genes (stx genes) and the locus of enterocyte effacement (LEE). Non-O157 EHECs belonging to distinct clonal lineages from O157...

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Identifiers

PMID: 17711596
DOI: 10.1186/gb-2007-8-7-r138
PMCID: PMC2323221

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