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Genome structural variation in Escherichia coli O157:H7

9 Nov 2021

Abstract excerpt

The human zoonotic pathogen Escherichia coli O157:H7 is defined by its extensive prophage repertoire including those that encode Shiga toxin, the factor responsible for inducing life-threatening pathology in humans. As well as introducing genes that can contribute to the virulence of a strain, prophage can enable the generation of large-chromosomal rearrangements (LCRs) by homologous recombination. This work...

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PMID: 34751643
DOI: 10.1099/mgen.0.000682

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