Topological importance of CD8 + T-cell enrichment in the tumor microenvironment of classic Hodgkin lymphoma

Abstract excerpt

<title>Abstract</title> <p>Classic Hodgkin lymphoma (CHL) histologically consists of Hodgkin Reed-Sternberg (HRS) cells and the tumor microenvironment (TME), but the relationship between TME characteristics and clinical features of CHL remains unclear. We aimed to investigate the effects of the TME structure on the outcomes of patients with CHL. We performed a high-throughput analysis of HRS cells and their topol...

Topics

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• Cancer Immunotherapy and Biomarkers
• CNS Lymphoma Diagnosis and Treatment
• Gene Expression Profiling
• Hodgkin Disease
• Immune Cell Function and Interaction
• Lymphoma Diagnosis and Treatment
• Mutation
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

320796c6-1a52-5a10-8be2-583f47bcf41c

DOI

10.21203/rs.3.rs-4458312/v1