Multidimensional characterization of cellular ecosystems in Hodgkin lymphoma

Abstract excerpt

<h4>SUMMARY</h4> The tissue architecture of classic Hodgkin Lymphoma (CHL) is unique among cancers and characterized by rare malignant Hodgkin and Reed-Sternberg cells that co-evolve with a complex ecosystem of immune cells in the tumor microenvironment (TME). The lack of a comprehensive systems-level interrogation has hindered the description of disease heterogeneity and clinically relevant molecular subtypes. H...

Topics

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• CAR-T cell therapy research
• CNS Lymphoma Diagnosis and Treatment
• Gene Expression Profiling
• Hodgkin Disease
• Lymphoma Diagnosis and Treatment
• Mutation
• Single-cell and spatial transcriptomics
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

f7272c58-2e09-5362-a110-f499019a5c5e

DOI

10.1101/2025.03.18.643177