Article
Generation of the human induced pluripotent stem cell line (SHAMUi001-A) carrying the heterozygous c.-128G>T mutation in the 5'-UTR of the ANKRD26 gene.
Stem cell research - 1 Oct 2020
Tan Chengning, Dai Limeng, Yang Wuchen, Li Fengjie, Wang Li, Xiao Yanni, Wang Xiaojie, Zhang Yichi, Wang Yali, Zeng Cheng, Xiang Zheng, Zhang Xiaomei, Zhang Weiwei, Ran Qian, Chen Maoshan, Li Zhongjun, Chen Li
Abstract excerpt
Thrombocytopenia 2 (THC2) is a major type of inherited thrombocytopenia caused by the persistent ANKRD26 expression during the late stage of megakaryocytopoiesis. For the first time, we generated a human induced pluripotent stem cell (hiPSC) line SHAMUi001-A from the bone marrow hematopoietic progenitor cells of a THC2 patient, who has a heterozygous mutation (c.-128G>T) in the 5'-UTR of ANKRD26 gene. SHAMUi001-A...
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