Article

Non-integrating direct reprogramming generates therapeutic endothelial cells with sustained vascular regeneration capacity enhanced by nanomatrix delivery

2025-09-25

Abstract excerpt

<h4>Rationale</h4> Direct reprogramming of fibroblasts into endothelial cells (rECs) using ETV2 shows promise for vascular regeneration. However, current approaches using integrating viral vectors pose clinical translation barriers, and poor long-term cell survival limits therapeutic efficacy. <h4>Objective</h4> To develop a clinically compatible method for generating rECs using non-integrating adenoviral ETV2 (...

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Literature Corpus work: 318977dc-db22-5c65-9e7c-b025a27f5248
DOI: 10.1101/2025.09.24.678308

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