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Article

Pemetrexed induces ROS generation and cellular senescence by attenuating TS-mediated thymidylate metabolism to reverse gefitinib resistance in NSCLC.

Journal of cellular and molecular medicine - 1 Jul 2023

Chen Yun, Zhang Chen, Jin Shidai, Li Jun, Dai Jiali, Zhang Zhihong, Guo Renhua

Abstract excerpt

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) are strongly recommended for non-small-cell lung cancer (NSCLC) patients harbouring active EGFR mutations, while drug resistance makes exploring resistance mechanisms and seeking effective therapeutic strategies urgent endeavours. Thymidylate synthetase (TYMS or TS) is a dominant enzyme in thymidylate nucleotide metabolism. In this study, we...

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Source

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Identifiers

PMID: 37278440
DOI: 10.1111/jcmm.17799
PMCID: PMC10339075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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