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Article

Intramyocellular lipid excess in the mitochondrial disorder MELAS

26 May 2017

Abstract excerpt

OBJECTIVE: There is a paucity of objective, quantifiable indicators of mitochondrial disease available for clinical and scientific investigation. METHODS: To this end, we explore intramyocellular lipid (IMCL) accumulation noninvasively by 7T magnetic resonance spectroscopy (MRS) as a reporter of metabolic dysfunction in MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). We...

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PMID: 28589178
DOI: 10.1212/nxg.0000000000000160

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