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TP53 mutations are associated with very complex karyotype and suggest poor prognosis in newly diagnosed myelodysplastic syndrome patients with monosomal karyotype.

Asia-Pacific journal of clinical oncology - 1 Jun 2020

Ren Yanling, Wang Jinghan, Zhang Hua, Mei Chen, Ye Li, Luo Yingwan, Zhou Xinping, Zhu Shuanghong, Jiang Lingxu, Wang Lu, Jin Jie, Tong Hongyan

Abstract excerpt

AIM: The aim of this study was to evaluate the clinical and molecular characteristics of myelodysplastic syndrome (MDS) patients with monosomal karyotype (MK). METHODS: Eighty MDS patients with MK diagnosed between January 2010 and December 2018 were included in the retrospective study. Seventy-three had complex karyotype (CK) and 46 had very CK (vCK, ≥ 5 abnormalities). Clinical information was collected, and a...

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Karyotyping
Monosomy
Mutation
Myelodysplastic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

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PMID: 32030889
DOI: 10.1111/ajco.13316

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