Article
Characterization of TP53 mutations in low-grade myelodysplastic syndromes and myelodysplastic syndromes with a non-complex karyotype.
European journal of haematology - 1 Dec 2017
Wang Wei, Routbort Mark J, Tang Zhenya, Ok Chi Young, Patel Keyur P, Daver Naval, Garcia-Manero Guillermo, Medeiros L Jeffrey, Wang Sa A
Abstract excerpt
OBJECTIVES: Although commonly associated with high-grade myelodysplastic syndrome (MDS) and MDS with a complex karyotype, TP53 mutations also occur in low-grade MDS and MDS with a non-complex karyotype. In latter cases, their clinicopathological features and the characteristics of TP53 mutations remain poorly characterized. METHODS: 176 MDS cases with TP53 mutations were stratified and characterized based on...
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