Article

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924

2024-12-16

Abstract excerpt

<title>Abstract</title> <p>A growing body of knowledge implicates perturbed RNA homeostasis in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that currently has no cure and few available treatments. Dysregulation of the multifunctional RNA-binding protein TDP-43 is increasingly regarded as a convergent feature of this disease, evidenced at the neuropathological level by the detection of TDP-43 p...

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Literature Corpus work: 312a5f80-aae7-523d-ba80-13d736d87156
DOI: 10.21203/rs.3.rs-5404388/v1

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