Article

Hi-C deconvolution of a human gut microbiome yields high-quality draft genomes and reveals plasmid-genome interactions

2017-10-05

Abstract excerpt

The assembly of high-quality genomes from mixed microbial samples is a long-standing challenge in genomics and metagenomics. Here, we describe the application of ProxiMeta, a Hi-C-based metagenomic deconvolution method, to deconvolve a human fecal metagenome. This method uses the intra-cellular proximity signal captured by Hi-C as a direct indicator of which sequences originated in the same cell, enabling culture-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30e15b85-a6dc-5e72-9189-05feabb9d8de
DOI: 10.1101/198713

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hi-C deconvolution of a human gut microbiome yields high-quality draft genomes and reveals plasmid-genome interactionsDOI 10.1101/198713Read

METAHIT enables comprehensive and flexible genome-resolved microbiome analysis with metagenomic Hi-CSemantic proximity Read

Highly accurate metagenome-assembled genomes from human gut microbiota using long-read assembly, binning, and consolidation methodsSemantic proximity Read

Hybrid, ultra-deep metagenomic sequencing enables genomic and functional characterization of low-abundance species in the human gut microbiomeSemantic proximity Read

HiFi Metagenomic Sequencing Enables Assembly of Accurate and Complete Genomes from Human Gut MicrobiotaSemantic proximity Read

Exploring high-quality microbial genomes by assembling short-reads with long-range connectivitySemantic proximity Read

Tracking microbial evolution in the human gut using Hi-CSemantic proximity Read

High-resolution metagenome assembly for modern long reads with myloasmSemantic proximity Read

Exploring high-quality microbial genomes by assembling short-reads with long-range connectivitySemantic proximity Read

Illumina Complete Long Read Assay yields contiguous bacterial genomes from human gut metagenomesSemantic proximity Read

End-to-end evaluation of pipelines for metagenome-assembled genomes reveals hidden performance gapsSemantic proximity Read

MetaTrass: High-quality metagenome assembly on the human gut microbiome by co-barcoding sequencing readsSemantic proximity Read

Scalable microbial strain inference in metagenomic data using StrainFactsSemantic proximity Read