Article

METAHIT enables comprehensive and flexible genome-resolved microbiome analysis with metagenomic Hi-C

2025-10-14

Abstract excerpt

Metagenomic Hi-C (metaHi-C) augments shotgun sequencing with in-cell proximity information, enabling genome-resolved analysis of complex communities. However, computational tools for metaHi-C remain fragmented and rarely offer end-to-end, comprehensive analysis, and existing pipelines use only chimeric Hi-C pairs while ignoring non-chimeric reads, which often constitute a large fraction of Hi-C libraries. Here, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00cea3d3-6df9-54aa-9438-741ca91b93e3
DOI: 10.1101/2025.10.12.681839

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

METAHIT enables comprehensive and flexible genome-resolved microbiome analysis with metagenomic Hi-CDOI 10.1101/2025.10.12.681839Read

End-to-end evaluation of pipelines for metagenome-assembled genomes reveals hidden performance gapsSemantic proximity Read

HiFi Metagenomic Sequencing Enables Assembly of Accurate and Complete Genomes from Human Gut MicrobiotaSemantic proximity Read

Highly accurate metagenome-assembled genomes from human gut microbiota using long-read assembly, binning, and consolidation methodsSemantic proximity Read

High-resolution metagenome assembly for modern long reads with myloasmSemantic proximity Read

Accurate profiling of microbial communities for shotgun metagenomic sequencing with Meteor2Semantic proximity Read

Hybrid, ultra-deep metagenomic sequencing enables genomic and functional characterization of low-abundance species in the human gut microbiomeSemantic proximity Read

MAGinator enables strain-level quantification of <i>de novo</i> MAGsSemantic proximity Read

High resolution shotgun metagenomics: the more data, the better?Semantic proximity Read

Illumina Complete Long Read Assay yields contiguous bacterial genomes from human gut metagenomesSemantic proximity Read

Exploring high-quality microbial genomes by assembling short-reads with long-range connectivitySemantic proximity Read

Implications of error-prone long-read whole-genome shotgun sequencing on characterizing reference microbiomesSemantic proximity Read

Hi-C deconvolution of a human gut microbiome yields high-quality draft genomes and reveals plasmid-genome interactionsSemantic proximity Read