Article

Stable Transmission of DNA Methylation Epimutations from Germlines to the Liver and Their Association with Fatty Liver Disease in Medaka

2025-02-14

Abstract excerpt

<title>Abstract</title> <p>Background Environmental stressors can induce heritable traits in organisms across phyla, with distinct epigenetic alterations in gametes and phenotypic outcomes across several generations. However, the mechanisms underlying such intergenerational inheritance, mainly from the germline to the germline and from the germline to the soma, are enigmatic, given that postfertilization embryos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30cfbf7b-0fbc-5efb-99e4-8092d0df1700
DOI: 10.21203/rs.3.rs-6010210/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stable Transmission of DNA Methylation Epimutations from Germlines to the Liver and Their Association with Fatty Liver Disease in MedakaDOI 10.21203/rs.3.rs-6010210/v1Read

Medaka liver developed Human NAFLD-NASH transcriptional signatures in response to ancestral bisphenol A exposureSemantic proximity Read

Sex-specific expression of the human NAFLD-NASH transcriptional signatures in the liver of medaka with a history of ancestral bisphenol A exposureSemantic proximity Read

The PCOS-NAFLD Multidisease Phenotype Occurred in Medaka Fish Four Generations after the Removal of Bisphenol A Exposure.Semantic proximity Read

Sperm miR-142-3p reprogramming mediates paternal stress-induced non-alcoholic steatohepatitis in offspring ratsSemantic proximity Read

Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations.Semantic proximity Read

Sperm miR‐142‐3p Reprogramming Mediates Paternal Pre‐Pregnancy Caffeine Exposure‐Induced Non‐Alcoholic Steatohepatitis in Male Offspring RatsSemantic proximity Read

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspringSemantic proximity Read

Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression TrajectoriesSemantic proximity Read

Epigenetics factors in nonalcoholic fatty liver diseaseSemantic proximity Read

Unraveling the Epigenetic Basis of Liver Development, Regeneration and DiseaseSemantic proximity Read

Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology.Semantic proximity Read

Sex-specific multigenerational epigenetic responses to real-world chemical mixture exposure in an outbred sheep modelSemantic proximity Read