Article

NCX1 disturbs calcium homeostasis, and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma

2022-07-13

Abstract excerpt

Although several types of calcium channels abnormalities have been shown to promote myeloma bone disease (MBD), the relationship between Na + /Ca 2+ exchanger 1 (NCX1) and MBD remains unexplored. Here, we examined the role of NCX1 in the development of multiple myeloma (MM), with a special focus on the underlying effects involved osteoclast differentiation. Firstly, we detected NCX1 protein was highly expressed in...

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Literature Corpus work: 30c8f20f-0d0b-5b1e-9297-ec188304b784
DOI: 10.21203/rs.3.rs-1828065/v1

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