Article

Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression

2023-04-13

Abstract excerpt

<title>Abstract</title> <p>The molecular mechanism of glioblastoma multiforme (GBM) spread in the brain remains poorly understood. Here, we investigated the mechanism underlying intracranial GBM progression. We found that the mitochondria-derived peptide, humanin, enhances GBM progression via intra-tumoral activation of the integrin alpha V (ITGAV)–TGF beta (TGFβ) signaling axis. In GBM tissues, humanin was signi...

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Literature Corpus work: 30c5a641-c322-546a-b06a-39b27d1a1d0d
DOI: 10.21203/rs.3.rs-2702693/v1

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