Article

PERK-mediated induction of miR-5p and miR-3p arms of miR-616 regulates cell growth by targeting c-MYC

2023-03-08

Abstract excerpt

<h4>ABSTRACT</h4> C/EBP homologous protein (CHOP), also known as DNA damage-inducible transcript 3 (DDIT3), is a member of CCAAT/enhancer-binding protein (C/EBP) family. The expression of CHOP is upregulated during unfolded protein response (UPR), and sustained CHOP activity plays an important role in UPR-induced apoptosis. MicroRNA-616 is localized in an intron of the CHOP gene. However, regulation of miR-616 ex...

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Literature Corpus work: 3082deab-06fa-5c4a-8675-71998c199789
DOI: 10.1101/2023.03.06.531445

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