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Article

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

Genes & development - 15 Feb 1994

Barone M V, Crozat A, Tabaee A, Philipson L, Ron D

Abstract excerpt

The growth arrest and DNA damage-inducible gene CHOP (GADD153) encodes a small nuclear protein from the C/EBP family, originally isolated from adipocytes in culture. Although inactive in cells under normal conditions, the CHOP gene is markedly induced by a variety of cellular stresses, including nutrient deprivation and metabolic perturbations. These lead to accumulation of CHOP protein in the nucleus. Because...

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Source

Identifiers

PMID: 8125258
DOI: 10.1101/gad.8.4.453

Genes

EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.PMID 8125258Read ↗

Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS-CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function.Semantic proximity Read ↗

C/EBPα Regulation of the Growth-Arrest-Associated Gene gadd45Semantic proximity Read ↗

The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomasSemantic proximity Read ↗

Induction of a secreted protein by the myxoid liposarcoma oncogeneSemantic proximity Read ↗

Transcription Factor C/EBP Homologous Protein in Health and DiseasesSemantic proximity Read ↗

Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-beta during adipogenesis.Semantic proximity Read ↗

PERK-mediated induction of miR-5p and miR-3p arms of miR-616 regulates cell growth by targeting c-MYCSemantic proximity Read ↗

Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumorsSemantic proximity Read ↗

Molecular Symbiosis of CHOP and C/EBPβ Isoform LIP Contributes to Endoplasmic Reticulum Stress-Induced ApoptosisSemantic proximity Read ↗

Stress-Inducible Transcription Factor CHOP/gadd153 Induces Apoptosis in Mammalian Cells via p38 Kinase-Dependent and -Independent MechanismsSemantic proximity Read ↗

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic β-cellsSemantic proximity Read ↗

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcomaSemantic proximity Read ↗

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