Article
CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.
Genes & development - 15 Feb 1994
Barone M V, Crozat A, Tabaee A, Philipson L, Ron D
Abstract excerpt
The growth arrest and DNA damage-inducible gene CHOP (GADD153) encodes a small nuclear protein from the C/EBP family, originally isolated from adipocytes in culture. Although inactive in cells under normal conditions, the CHOP gene is markedly induced by a variety of cellular stresses, including...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Bromodeoxyuridine
- CCAAT-Enhancer-Binding Proteins
- DNA Damage
- DNA-Binding Proteins
- G1 Phase
- Genetic Variation
- Humans
- Leucine Zippers
- Liposarcoma, Myxoid
- Mice
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Oncogene Proteins
- S Phase