Article
Cross-neutralization of influenza A viruses mediated by a single antibody loop.
Nature - 27 Sept 2012
Ekiert Damian C, Kashyap Arun K, Steel John, Rubrum Adam, Bhabha Gira, Khayat Reza, Lee Jeong Hyun, Dillon Michael A, O'Neil Ryann E, Faynboym Aleksandr M, Horowitz Michael, Horowitz Lawrence, Ward Andrew B, Palese Peter, Webby Richard, Lerner Richard A, Bhatt Ramesh R, Wilson Ian A
Abstract excerpt
Immune recognition of protein antigens relies on the combined interaction of multiple antibody loops, which provide a fairly large footprint and constrain the size and shape of protein surfaces that can be targeted. Single protein loops can mediate extremely high-affinity binding, but it is unclear whether such a mechanism is available to antibodies. Here we report the isolation and characterization of an...
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