Article

Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer

2024-03-05

Abstract excerpt

<h4>Purpose: </h4> Lysine methyltransferase 5A (KMT5A) is the sole mammalian enzyme known to catalyze the monomethylation of histone H4 lysine 20 and nonhistone proteins such as p53, which are involved in the occurrence and progression of many cancers. Our study aimed to determine the function of KMT5A in inducing docetaxel resistance in patients with breast carcinoma by evaluating glucose metabolism and the under...

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Literature Corpus work: 2fd8f4f4-8be6-5ad3-8546-b94a89cd8f32
DOI: 10.21203/rs.3.rs-3998544/v1

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