Article

Androgen Drives Melanoma Invasiveness and Metastatic Capacity by Promoting Tumorigenic Fucosylation

2023-03-10

Abstract excerpt

<title>Abstract</title> <p>Melanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles for the male sex hormone androgen and its receptor (AR) in melanoma, cellular and molecular mechanisms underlying these sex-associated discrepancies are poorly defined. Here, we delineate a novel mechanism by which androgen-activated AR transcri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f932b95-12d9-5c03-aa16-3efc26569c6c
DOI: 10.21203/rs.3.rs-2623307/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Androgen Drives Melanoma Invasiveness and Metastatic Capacity by Promoting Tumorigenic FucosylationDOI 10.21203/rs.3.rs-2623307/v1Read

Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylationSemantic proximity Read

Role of Androgen Receptor in Melanoma: Mechanisms of Tumor Progression, Immune Evasion, and Therapeutic ImplicationsSemantic proximity Read

FRA1 drives melanoma metastasis through an actionable transcriptional networkSemantic proximity Read

Expression of fucosyltransferases contributes to melanoma invasive phenotype.Semantic proximity Read

Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesisSemantic proximity Read

TEAD1 regulates ITGA1 and ITGA2 to control prostate cancer progressionSemantic proximity Read

hMAGEA2 Promotes Cell Growth and Tumorigenicity in MelanomaSemantic proximity Read

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expressionSemantic proximity Read

The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancerSemantic proximity Read

DGAT1 as a Racially Divergent Driver of Carcinoma-Associated Fibroblast Activation Drives Tumorigenic Pathways via ERK1/2 Signaling in Prostate CancerSemantic proximity Read

The small MAF transcription factor MAFG co-opts MITF to promote melanoma progressionSemantic proximity Read

Dampened Regulatory Circuitry of TEAD1/ITGA1/ITGA2 Promotes TGFβ1 Signaling to Orchestrate Prostate Cancer ProgressionSemantic proximity Read