Article

Construction of a genome-wide pooled CRISPRi library as a resource for exploring the acid tolerance mechanism in Streptococcus mutans

2025-07-22

Abstract excerpt

Streptococcus mutans is recognized as the primary etiological agent of dental caries, one of the most prevalent infectious diseases globally. Its remarkable acid tolerance enables survival and proliferation in the low-pH biofilm microenvironment, establishing S. mutans as the dominant species in dental plaque and a key contributor to cariogenesis. Although numerous studies have identified genes linked to acid tol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f91fe2a-5625-51d6-bfd6-b77df4f989af
DOI: 10.1101/2025.07.22.666072

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Construction of a genome-wide pooled CRISPRi library as a resource for exploring the acid tolerance mechanism in Streptococcus mutansDOI 10.1101/2025.07.22.666072Read

Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene FunctionSemantic proximity Read

Comparing the cariogenic speciesStreptococcus sobrinusandS. mutanson whole genome levelSemantic proximity Read

Genomic instability and biofilm determinants in Streptococcus mutans : insights from a sequence-defined arrayed transposon librarySemantic proximity Read

SMU_1361c regulates the oxidative stress response of Streptococcus mutansSemantic proximity Read

Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants.Semantic proximity Read

Guardian genes ensuring subsistence of oral Streptococcus mutansSemantic proximity Read

Genomic and phenotypic characterization of Streptococcus mutans isolates suggests key gene clusters in regulating its interaction with Streptococcus gordoniiSemantic proximity Read

Analysis of the Streptococcus mutans proteome during acid and oxidative stress reveals modules of co-expression and an expanded role for the TreR transcriptional regulatorSemantic proximity Read

Genome-wide identification of novel sRNAs in Streptococcus mutansSemantic proximity Read

Gene Regulation in S. mutansSemantic proximity Read

Genomewide Identification of Essential Genes and Fitness Determinants of Streptococcus mutans UA159Semantic proximity Read

Mobile-CRISPRi: Enabling Genetic Analysis of Diverse BacteriaSemantic proximity Read

Construction of a genome-wide pooled CRISPRi library as a resource for exploring the acid tolerance mechanism in <i>Streptococcus mutans</i>

Abstract excerpt

Topics

Identifiers and source

Related research