Article

Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria

2020-11-06

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in genes encoding the human brain-expressed voltage-gated sodium (Na V ) channels Na V 1.1, Na V 1.2, and Na V 1.6 are associated with a variety of human diseases including epilepsy, autism spectrum disorder, familial migraine, and other neurodevelopmental disorders. A major obstacle hindering investigations of the functional consequences of brain Na V channel mutations is an unex...

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Literature Corpus work: 2f70856e-4fea-57dd-bc8c-9eebaef50711
DOI: 10.1101/2020.11.05.370429

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