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A stromal activation signature informed by single-cell fibroblast analysis is associated with prognosis in gastric cancer

2026-08-03

Abstract excerpt

<title>Abstract</title> <p>Cancer-associated fibroblasts (CAFs) contribute to extracellular-matrix remodeling and tumor-stroma interactions in gastric cancer, but translating single-cell fibroblast heterogeneity into reproducible patient-level readouts remains challenging. We integrated tumor-focused single-cell analysis with bulk transcriptomic survival modeling to derive and externally evaluate a CAF-related st...

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Literature Corpus work
2f6825e8-da1a-561e-a0a0-b58f92ce4ef7
DOI
10.21203/rs.3.rs-10016782/v1
Open publication

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A stromal activation signature informed by single-cell fibroblast analysis is associated with prognosis in gastric cancerDOI 10.21203/rs.3.rs-10016782/v1
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