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Distinct cellular and transcriptional mechanisms mediate an antioxidant therapeutic response in 22q11-deleted upper layer cortical projection neurons

2025-12-08

Abstract excerpt

<h4>ABSTRACT</h4> We characterized cellular and molecular mechanisms underlying the therapeutic response in vitro and in vivo to the antioxidant N-acetyl cysteine (NAC), which in the LgDel 22q11.2 Deletion Syndrome mouse model restores growth and connectivity of upper layer cortical projection neurons ( L ayer 2/3 PNs) and improves cognitive performance. NAC treatment of primary cultured LgDel L 2/3 PNs does...

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Literature Corpus work
2f630342-72ac-5ba0-9778-6075c948930d
DOI
10.64898/2025.12.03.692138
Open publication

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