Article
Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis.
Nature communications - 18 Apr 2018
Weyemi Urbain, Paul Bindu D, Snowman Adele M, Jailwala Parthav, Nussenzweig Andre, Bonner William M, Snyder Solomon H
Abstract excerpt
ATM drives DNA repair by phosphorylating the histone variant H2AX. While ATM mutations elicit prominent neurobehavioral phenotypes, neural roles for H2AX have been elusive. We report impaired motor learning and balance in H2AX-deficient mice. Mitigation of reactive oxygen species (ROS) with N-acetylcysteine (NAC) reverses the behavioral deficits. Mouse embryonic fibroblasts deficient for H2AX exhibit increased...
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