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Article

Sleep-disordered Breathing in Newborn Mice Heterozygous for the Transcription Factor Phox2b

28 Apr 2005

Abstract excerpt

RATIONALE: Central congenital hypoventilation syndrome (CCHS) is a rare autosomal dominant syndrome present from birth, and characterized by depressed ventilation during sleep. Heterozygous mutations of the homeobox gene Phox2b were recently found in a very high proportion of patients. OBJECTIVES: To determine whether newborn mice with heterozygous targeted deletion of the transcription factor Phox2b would...

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PMID: 15860752
DOI: 10.1164/rccm.200411-1528oc

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