Article

VapC12 ribonuclease toxin modulates host immune response during <i>Mycobacterium tuberculosis</i> infection

2023-08-25

Abstract excerpt

Mechanistic understanding of antibiotic persistence is a prerequisite in controlling the emergence of MDR cases in Tuberculosis (TB). We have reported that the cholesterol-induced activation of VapC12 ribonuclease is critical for disease persistence in TB. In this study, we observed that relative to the wild type, mice infected with Δ vapC12 induced a proinflammatory response, had a higher pathogen load, and resp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f1f10b5-b393-519f-a28b-fc3ff57ac2a3
DOI: 10.1101/2023.08.24.554572

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

VapC12 ribonuclease toxin modulates host immune response during <i>Mycobacterium tuberculosis</i> infectionDOI 10.1101/2023.08.24.554572Read

VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection.Semantic proximity Read

Immunoevasion and immunosuppression of the macrophage by <i><scp>M</scp>ycobacterium tuberculosis</i>Semantic proximity Read

Distinct Persistence Fate of Mycobacterium tuberculosis in Various Types of CellsSemantic proximity Read

Pathogen roid rage: Cholesterol utilization by<i>Mycobacterium tuberculosis</i>Semantic proximity Read

Mycobacterium tuberculosis : Rewiring host cell signaling to promote infectionSemantic proximity Read

<i>Mycobacterium tuberculosis</i>and the host responseSemantic proximity Read

Mycobacterium avium subspecies paratuberculosis is able to manipulate host lipid metabolism and accumulate cholesterol within macrophagesSemantic proximity Read

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosisSemantic proximity Read

Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis.Semantic proximity Read

Virulence factors of the<i>Mycobacterium tuberculosis</i>complexSemantic proximity Read

Autophagy protects against high-dose <i>Mycobacterium tuberculosis</i> infectionSemantic proximity Read

Tobramycin enhances <i>Mycobacterium abscessus</i> fitness through <i>whiB7</i> inductionSemantic proximity Read