Article
VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection.
Frontiers in immunology - 1 Jan 2024
Tyagi Shaifali, Sadhu Srikanth, Sharma Taruna, Paul Abhijit, Pandey Manitosh, Nain Vaibhav Kumar, Rathore Deepak Kumar, Chatterjee Samrat, Awasthi Amit, Pandey Amit Kumar
Abstract excerpt
Mechanistic understanding of antibiotic persistence is a prerequisite in controlling the emergence of MDR cases in Tuberculosis (TB). We have reported that the cholesterol-induced activation of VapC12 ribonuclease is critical for disease persistence in TB. In this study, we observed that relative to the wild type, mice infected with ΔvapC12 induced a pro-inflammatory response, had a higher pathogen load, and...
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