Article

Organ Boundary Circuits Regulate Sox9+ Alveolar Tuft Cells During Post-Pneumonectomy Lung Regeneration

2024-01-08

Abstract excerpt

Tissue homeostasis is controlled by cellular circuits governing cell growth, organization, and differentation. In this study we identify previously undescribed cell-to-cell communication that mediates information flow from mechanosensitive pleural mesothelial cells to alveolar-resident stem-like tuft cells in the lung. We find mesothelial cells to express a combination of mechanotransduction genes and lineage-rest...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24644c40-85fe-518c-9bb6-6fd6c85ca4d7
DOI: 10.1101/2024.01.07.574469

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Organ Boundary Circuits Regulate Sox9+ Alveolar Tuft Cells During Post-Pneumonectomy Lung RegenerationDOI 10.1101/2024.01.07.574469Read

The lung mesenchyme in development, regeneration, and fibrosisSemantic proximity Read

Understanding alveolarization to induce lung regenerationSemantic proximity Read

Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature.Semantic proximity Read

Pleura Organoid Transplantation Facilitates Visceral Pleural Repair through CD133+ Progenitor Cell-Mediated RegenerationSemantic proximity Read

Extracellular matrix as a driver of progressive fibrosisSemantic proximity Read

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regenerationSemantic proximity Read

An injury-induced tissue niche shaped by mesenchymal plasticity coordinates the regenerative and disease response in the lungSemantic proximity Read

A smooth muscle-like niche facilitates lung epithelial regenerationSemantic proximity Read

Human club cells derived from pluripotent stem cells reveal new insights into epithelial lineage plasticity through structural and functional validationSemantic proximity Read

Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process?Semantic proximity Read

Lung epithelial stem cells and their niches: Fgf10 takes center stageSemantic proximity Read

Ureter single-cell and spatial mapping reveal cell types, architecture, and signaling networksSemantic proximity Read