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PARP inhibition in Ewing sarcoma: impact of germline DNA damage repair defects and activation of immunoregulatory pathways

2020-09-19

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma, an oncofusion-driven primary bone tumor, can occur in the setting of various germline mutations in DNA damage repair pathway genes. We recently reported our discovery of a germline mutation in the DNA damage repair protein BARD1 (BRCA1-associated RING domain-1) in a patient with Ewing sarcoma. BARD1 is recruited to the site of DNA double stranded breaks via the poly(ADP-ribose) p...

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Literature Corpus work
2ed4de90-8724-5c6a-b4c3-3e1dc6208273
DOI
10.1101/2020.09.18.304238
Open publication

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PARP inhibition in Ewing sarcoma: impact of germline DNA damage repair defects and activation of immunoregulatory pathwaysDOI 10.1101/2020.09.18.304238
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