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Massive parallel sequencing unveils homologous recombination deficiency in follicular dendritic cell sarcoma.

Haematologica - 1 Jun 2024

Lorenzi Luisa, Haferlach Torsten, Mori Luigi, Simbeni Matteo, Walter Wencke, Balzarini Piera, Meggendorfer Manja, Döring Claudia, Lonardi Silvia, Bugatti Mattia, Agostinelli Claudio, Mehta Jay, Borges Anita, Agaimy Abbas, Simonitsch-Klupp Ingrid, Cabeçadas José, Campo Elias, Pileri Stefano Aldo, Facchetti Fabio, Leo Hansmann Martin, Hartmann Sylvia

Abstract excerpt

Standardized treatment options are lacking for patients with unresectable or multifocal follicular dendritic cell sarcoma (FDCS) and disease-related mortality is as high as 20%. Applying whole-genome sequencing (WGS) in one case and whole-exome sequencing (WES) in additional twelve cases, this study adds information on the molecular landscape of FDCS, expanding knowledge on pathobiological mechanisms and...

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Identifiers

PMID: 37994105
DOI: 10.3324/haematol.2023.283669
PMCID: PMC11141687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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