Article
A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity.
Science advances - 1 Feb 2020
Akkaya Munir, Bansal Abhisheka, Sheehan Patrick W, Pena Mirna, Molina-Cruz Alvaro, Orchard Lindsey M, Cimperman Clare K, Qi Chen-Feng, Ross Philipp, Yazew Takele, Sturdevant Daniel, Anzick Sarah L, Thiruvengadam Girija, Otto Thomas Dan, Billker Oliver, Llinás Manuel, Miller Louis H, Pierce Susan K
Abstract excerpt
The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host's ability to mount a protective immune response. Here, we show that a single-nucleotide polymorphism (SNP) resulting in a single amino acid change (S to F) in an ApiAP2 transcription factor in the rodent malaria parasite Plasmodium berghei (Pb) NK65...
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