Article

Elucidating the mechanistic impact of single nucleotide variants in model organisms

2018-01-01

Abstract excerpt

Understanding how genetic variation propagate to differences in phenotypes in individuals is an ongoing challenge in genetics. Genome-wide association studies have allowed for the identification of many trait-associated genomic loci. However, they are limited in their inability to explain the altered cellular mechanism. Genetic variation can drive disease by altering a range of mechanisms, including signalling net...

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Literature Corpus work: 2e4b859b-9876-502c-a0a4-a3184aadf463
DOI: 10.17863/cam.18705

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