Article

Major surgery induces acute changes in DNA methylation associated with activation of the immune response

2019-07-18

Abstract excerpt

<h4>Background</h4> Surgery is an invasive procedure evoking acute inflammatory and immune responses that are believed to mediate risk for postoperative complications including cognitive dysfunction and delirium. Although the specific mechanisms driving these responses have not been well-characterized, they are hypothesized to involve the epigenetic regulation of gene expression. We quantified genome-wide levels...

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Literature Corpus work: 2e28a987-f9ed-53be-9bf8-e29e3b8bcbf7
DOI: 10.1101/706184

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