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Major surgery induces acute changes in measured DNA methylation associated with immune response pathways

1 Apr 2020

Abstract excerpt

Surgery is an invasive procedure evoking acute inflammatory and immune responses that can influence risk for postoperative complications including cognitive dysfunction and delirium. Although the specific mechanisms driving these responses have not been well-characterized, they are hypothesized to involve the epigenetic regulation of gene expression. We quantified genome-wide levels of DNA methylation in...

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PMID: 32238836
DOI: 10.1038/s41598-020-62262-x

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