Article

HDAC2 inhibition restores H4K16 Acetylation and Rescues Cellular Senescence in Hutchinson-Gilford progeria syndrome

2025-11-07

Abstract excerpt

Histone H4K16 acetylation (H4K16ac) is a key epigenetic mark essential for chromatin structure and DNA repair, which is substantially reduced in the accelerated aging disorder Hutchinson-Gilford progeria syndrome (HGPS). The specific enzymes governing H4K16ac homeostasis, particularly the deacetylase responsible for its loss in HGPS, remain poorly defined. Here, we sought to identify the enzymes regulating H4K16ac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e26d738-6e2a-56c9-8f94-7b834421f6d4
DOI: 10.1101/2025.11.07.687234

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HDAC2 inhibition restores H4K16 Acetylation and Rescues Cellular Senescence in Hutchinson-Gilford progeria syndromeDOI 10.1101/2025.11.07.687234Read

Hutchinson-Gilford progeria syndrome through the lens of transcription.Semantic proximity Read

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.Semantic proximity Read

Early Polycomb-target deregulations in Hutchinson-Gilford Progeria Syndrome revealed by heterochromatin analysisSemantic proximity Read

A multiscale chromatin collapse underlies vascular pathology in Hutchinson–Gilford progeria syndromeSemantic proximity Read

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria SyndromeSemantic proximity Read

Targeting SerpinE1 reverses cellular features of Hutchinson-Gilford progeria syndromeSemantic proximity Read

Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.Semantic proximity Read

Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype.Semantic proximity Read

The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesisSemantic proximity Read

Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancerSemantic proximity Read

Pak2 kinase promotes cellular senescence and organismal agingSemantic proximity Read

Deacetylation of H4-K16Ac and heterochromatin assembly in senescenceSemantic proximity Read