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A protocol for a systematic review and individual patient data meta-analysis investigating the relationship between <i>Pfkelch13</i> mutations and response to artemisinin-based treatment for uncomplicated falciparum malaria

2025-02-06

Abstract excerpt

<h4>Introduction</h4> Artemisinin-based combination therapies (ACTs) remain the WHO-recommended treatment for uncomplicated Plasmodium falciparum malaria. However, the emergence and spread of artemisinin resistance (ART-R) threatens ACT efficacy. ART-R is phenotypically expressed as delayed parasite clearance, which can facilitate ACT partner drug resistance. ART-R has been causally linked to specific mutations...

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Literature Corpus work
2dcd7ec0-4307-5841-9c8e-127a24860e29
DOI
10.1101/2025.02.05.25321713
Open publication

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A protocol for a systematic review and individual patient data meta-analysis investigating the relationship between <i>Pfkelch13</i> mutations and response to artemisinin-based treatment for uncomplicated falciparum malariaDOI 10.1101/2025.02.05.25321713
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