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Delivery of multiple PspA fragments by CyaA toxoid induces broad protection against Streptococcus pneumoniae

2026-05-20

Abstract excerpt

<title>Abstract</title> <p> <italic>Streptococcus pneumoniae</italic> is a leading cause of lower respiratory tract (LRT) infections and invasive pneumococcal diseases (IPD). Conjugate vaccines are effective against IPD and nasal colonization but offer coverage limited to serotypes included in the formulations. Pneumococcal surface protein A (PspA) stands out as a promising vaccine antigen. We had previously sh...

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Literature Corpus work
2d9a0da3-7a30-5562-b4d9-9c55a584620d
DOI
10.21203/rs.3.rs-9542276/v1
Open publication

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Delivery of multiple PspA fragments by CyaA toxoid induces broad protection against Streptococcus pneumoniaeDOI 10.21203/rs.3.rs-9542276/v1
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