A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A.

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Article

A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1998

Yamamoto M, Briles D E, Yamamoto S, Ohmura M, Kiyono H, McGhee J R

Abstract excerpt

In this study, we demonstrated that pneumococcal surface protein A (PspA) nasally administered with a nontoxic A subunit mutant of cholera toxin (mCT) S61F elicited a protective immune response. Immunization with PspA and mCT elicited higher levels of PspA-specific IgG and IgA Abs in serum and of...

Topics

Adjuvants, Immunologic
Administration, Intranasal
Animals
Antigens, Bacterial
Bacterial Proteins
Bacterial Vaccines
Cholera Toxin
Immunity, Mucosal
Mice
Mice, Inbred C57BL
Mutation
Pneumococcal Infections

Source

Open in PubMed

Identifiers

PMID: 9780183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9780183-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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