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Article

A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1998

Yamamoto M, Briles D E, Yamamoto S, Ohmura M, Kiyono H, McGhee J R

Abstract excerpt

In this study, we demonstrated that pneumococcal surface protein A (PspA) nasally administered with a nontoxic A subunit mutant of cholera toxin (mCT) S61F elicited a protective immune response. Immunization with PspA and mCT elicited higher levels of PspA-specific IgG and IgA Abs in serum and of IgG and IgA anti-PspA Ab-forming cells in spleens, cervical lymph nodes (CLN), and lung tissue when compared to...

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Source

Identifiers

PMID: 9780183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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