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Trans-biobank Mendelian randomization analyses identify opposing pathways in plasma low-density lipoprotein-cholesterol lowering and gallstone disease

2023-09-27

Abstract excerpt

<h4>Structured abstract</h4> <h4>Background</h4> Plasma low-density lipoprotein (LDL)-cholesterol is positively associated with coronary artery disease risk while biliary cholesterol promotes gallstone formation. <h4>Objectives</h4> We tested the hypothesis that different plasma LDL-cholesterol lowering pathways have distinct effects on biliary cholesterol and thereby risk of gallstone disease. <h4>Methods</h4> Th...

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Literature Corpus work
2d6211eb-6cbb-5145-b48e-629ec5872816
DOI
10.1101/2023.09.27.23296205
Open publication

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Trans-biobank Mendelian randomization analyses identify opposing pathways in plasma low-density lipoprotein-cholesterol lowering and gallstone diseaseDOI 10.1101/2023.09.27.23296205
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