Article

BET inhibitor blocks the oncogenic function of nucleophosmin 1 in castration-resistant prostate cancer by interfering with the c-Myc signaling pathway

2022-05-31

Abstract excerpt

<h4>Background: </h4> Nucleophosmin 1 (NPM1) is a multifunctional protein that promotes tumor progression in some solid tumors and has also been reported to be capable of predicting poor prognosis of prostate cancer (PCa). However, whether and how NPM1 exerts such malignant potentials in castration-resistant prostate cancer (CRPC) remain elusive. <h4>Methods: </h4>: The effects of NPM1 on PCa and CRPC and the inte...

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Literature Corpus work: 2d5a109b-6618-5685-aabb-5cd0699cd863
DOI: 10.21203/rs.3.rs-1659620/v1

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