Article

Extreme ESR1 Polyclonality, Mutation Dynamics, and Effects on Treatment Outcomes in Patients with ER+ Metastatic Breast Cancer

2026-08-10

Abstract excerpt

<title>Abstract</title> <p>Purpose ESR1 mutations are commonly acquired on endocrine therapy (ET) and contribute to therapeutic resistance. The impact of increasing degrees of polyclonality - including dynamics of ESR1-mutant clones, co-occurring mutations, and treatment outcomes - is not well understood. Methods We conducted a retrospective, descriptive review of patients with estrogen receptor-positive (ER+) m...

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Literature Corpus work: 2d319f43-ee7c-5288-b17f-348d48685c76
DOI: 10.21203/rs.3.rs-8187308/v1

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