Article

Assessing Endocrine Resistance: Monitoring Circulating ESR1 mutations in Irosustat-Treated ER positive Breast Cancer

2025-08-07

Abstract excerpt

<title>Abstract</title> <p> <bold>Purpose:</bold> We aimed to investigate the prevalence and spectrum of <italic>ESR1</italic> mutations alongside cell-free DNA (cfDNA) dynamics in patients with estrogen receptor-positive metastatic breast cancer recruited to the phase II IRIS study who had progressed on first-line aromatase inhibitor (AI) therapy and then continued their AI in combination with Irusostat (40m...

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Literature Corpus work: cc10ce89-a738-546a-8b8d-75ba8abd5a03
DOI: 10.21203/rs.3.rs-7187693/v1

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