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Integrated metabolic modeling, culturing and transcriptomics explains enhanced virulence of <i>V. cholerae</i> during co-infection with ETEC

2020-06-18

Abstract excerpt

Gene essentiality is altered during polymicrobial infections. Nevertheless, most studies rely on single-species infections to assess pathogen gene essentiality. Here, we use genome-scale metabolic models to explore the effect of co-infection of the diarrheagenic pathogen Vibrio cholerae ( V. cholerae ) with another enteric pathogen, enterotoxigenic E. coli (ETEC). Model predictions showed that V. cholerae meta...

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Literature Corpus work
2d0ccc19-7402-5501-ad3f-f54aa359c33b
DOI
10.1101/2020.06.16.156158
Open publication

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Integrated metabolic modeling, culturing and transcriptomics explains enhanced virulence of <i>V. cholerae</i> during co-infection with ETECDOI 10.1101/2020.06.16.156158
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