Article
Phage predation, disease severity, and pathogen genetic diversity in cholera patients.
Science (New York, N.Y.) - 19 Apr 2024
Madi Naïma, Cato Emilee T, Abu Sayeed Md, Creasy-Marrazzo Ashton, Cuénod Aline, Islam Kamrul, Khabir Md Imam Ul, Bhuiyan Md Taufiqur R, Begum Yasmin A, Freeman Emma, Vustepalli Anirudh, Brinkley Lindsey, Kamat Manasi, Bailey Laura S, Basso Kari B, Qadri Firdausi, Khan Ashraful I, Shapiro B Jesse, Nelson Eric J
Abstract excerpt
Despite an increasingly detailed picture of the molecular mechanisms of bacteriophage (phage)-bacterial interactions, we lack an understanding of how these interactions evolve and impact disease within patients. In this work, we report a year-long, nationwide study of diarrheal disease patients in Bangladesh. Among cholera patients, we quantified Vibrio cholerae (prey) and its virulent phages (predators) using...
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