Article

Histone deacetylase inhibition by gut microbe-generated short chain fatty acids entrains intestinal epithelial circadian rhythms

2020-06-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and aims</h4> The circadian clock orchestrates ~24-hour oscillations of gastrointestinal (GI) epithelial structure and function that drive diurnal rhythms in the composition, localization, and metabolism of gut microbiota. Here, we use experimental and computational approaches in enteroids to reveal reciprocal effects of microbial metabolites on intestinal epithelial timekeeping...

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Literature Corpus work: 29d60f0a-77a1-5e0b-92a2-a562db430c7c
DOI: 10.1101/2020.06.09.143057

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