Article
The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils.
Cancer cell - 9 Apr 2018
Stammnitz Maximilian R, Coorens Tim H H, Gori Kevin C, Hayes Dane, Fu Beiyuan, Wang Jinhong, Martin-Herranz Daniel E, Alexandrov Ludmil B, Baez-Ortega Adrian, Barthorpe Syd, Beck Alexandra, Giordano Francesca, Knowles Graeme W, Kwon Young Mi, Hall George, Price Stacey, Pye Ruth J, Tubio Jose M C, Siddle Hannah V T, Sohal Sukhwinder Singh, Woods Gregory M, McDermott Ultan, Yang Fengtang, Garnett Mathew J, Ning Zemin, Murchison Elizabeth P
Abstract excerpt
Transmissible cancers are clonal lineages that spread through populations via contagious cancer cells. Although rare in nature, two facial tumor clones affect Tasmanian devils. Here we perform comparative genetic and functional characterization of these lineages. The two cancers have similar patterns of mutation and show no evidence of exposure to exogenous mutagens or viruses. Genes encoding PDGF receptors have...
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