Article

Structural Bioinformatics of Four Human Aquaporins and Their Water-Soluble QTY Analogs

2026-06-30

Abstract excerpt

Human a qua p orins (AQPs) are essential membrane channels, yet their inherent hydrophobicity complicates structural and functional studies. We present the systematic application of the QTY code to human AQPs, integrating it with AlphaFold 3 structure prediction to design and validate that four-representative human AQPs (AQP1, AQP3, AQP4, AQP7) can be converted into water-soluble analogs while maintaining their...

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Literature Corpus work: 2c146c87-3027-5df2-ae4d-8bd89bff7933
DOI: 10.64898/2026.06.24.734367

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